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当前位置>>科研成果
| 1. |
Gao FH, Wu YL, Zhao M, Liu CX, Wang LS, Chen GQ*. Protein Kinase C-δ mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction. Exp Cell Res. 2009;315:3250-3258.（IF：3.589） |
| 2. |
Liao SH, Zhao XY, Han YH, Zhang J, Wang LS, Xia L, Zhao KW, Zheng Y, Guo M, Chen GQ*. Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells. Proteomics. 2009;9:3901-3912（IF：4.426） |
| 3. |
Zhang J, Chen GQ*.Hypoxia-HIF-1α -C/EBPα /Runx1 signaling in leukemic cell differentiation. Pathophysiology. 2009;16:297-303 |
| 4. |
Zhao M, Duan X-F, Zhao X-Y, Zhang B, Lu Y, Liu W, Cheng JK, Chen GQ*. Protein kinase Cd stimulates proteasome-dependent degradation of C/EBPα during apoptosis induction of leukemic cells. PLoS ONE.2009; 4: e6552.（IF：4.351） |
| 5. |
Chen S, Han YH, Zheng Y, Zhao M, Yan H, Zhao Q, Chen GQ, Li D*. NDRG1 contributes to retinoic acid-induced differentiation of leukemic cells. Leuk Res. 2009;33:1108-1113（IF：2.358） |
| 6. |
Yuan TT, Huang Y, Zhou CX, Yu Y, Wang LS, Chen GQ*. Nuclear translocation of dihydrofolate reductase is not a pre-requisite for DNA damage induced apoptosis. Apoptosis. 2009;14:699-710（IF：4.066） |
| 7. |
Meng C, Jin X, Xia L, Shen SM, Wang XL, Cai J, Chen GQ, Wang LS*, Fang NY*. Alterations of mitochondrial enzymes contribute to cardiac hypertrophy before hypertension development in spontaneously hypertensive rats. J Proteome Res. 2009;8(5):2463-2475（IF：5.132） |
| 8. |
Zhao M, Duan XF, Wen DH, Chen GQ*.PU.1, a novel capase-3 substrate, partially contributes to chemotherapeutic agents-induced apoptosis in leukemic cells. Biochem Biophys Res Commun. 2009;382(3):508-513（IF：2.548） |
| 9. |
Zheng Y, Wang LS, Xia L, Han YH, Liao SH, Wang XL, Cheng JK, Chen GQ*.NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: The potential role in proteolytic activation of PKCd and apoptosis. Proteomics. 2009;9(8):2064-2075（IF：4.426） |
| 10. |
Zhang N, Zhang H, Xia L, Zheng Y, Yu Y, Zhu Y, Chen GQ*, Di W.*NSC606985 induces apoptosis, exerts synergistic effects with cisplatin, and inhibits hypoxia-stabilized HIF-1α protein in human ovarian cancer cells.Cancer Letters. 2009;278:139-144（IF：3.741） |
| 11. |
Huang C, Han Y, Wang Y, Sun X, Yan S, Yeh ET, Chen Y, Cang H, Li H, Shi G, Cheng J, Tang X, Yi J*.SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J. 2009;28:2748-2762（IF：8.993） |
| 12. |
Zuo Y, Xiang B, Yang J, Sun X, Wang Y, Cang H, Yi J*.Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1.Cell Res. 2009;19:449-457（IF：8.151） |
| 13. |
Wang R, Zou Y, Yuan Z, Wang Y, Chen Y, Mao Y, Zhu ZA, Li H, Tang X, Lu J, Yi J*.Autografts and xenografts of skin fibroblasts delivering BMP-2 effectively promote orthotopic and ectopic osteogenesis. Anat Rec (Hoboken). 2009;292:777-786（IF：1.49） |
| 14. |
Zhuang H*, Chien MS, Matsunami H*.Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.Proc Natl Acad Sci U S A. 2009;106:21247-21251（IF：9.432） |
| 15. |
Yu Z, Ji P, Cao J, Zhu S, Li Y, Zheng L, Chen X, Feng LX*.Dazl promotes germ cell differentiation from embryonic stem cells.J Mol Cell Biol. 2009;1:93-103 |
| 16. |
Tian H, Zhang N, Suo WH, Wang T, Song LJ, Wu J, Liu Q, Shen WW, Fu GH*. Gastrin suppresses the interdependent expression of p16 and anion exchanger 1 favoring growth inhibition of gastric cancer cells.Int J Cancer. 2009 Dec 17. [Epub ahead of print] （IF：4.722） |
| 17. |
Xu WQ, Song LJ, Liu Q, Zhao L, Zheng L, Yan ZW, Fu GH*.Expression of anion exchanger 1 is associated with tumor progress in human gastric cancer. J Cancer Res Clin Oncol. 2009;135:1323-1330 |
| 18. |
Zhao W, Zhu F, Shen WW, Fu A, Zheng L, Yan Z, Zhao L, Fu GH*.Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats. Acta Biochim Biophys Sin (Shanghai). 2009;41:301-308（IF：1.482） |
| 19. |
Liu Q, Song LJ, Xu WQ, Zao L, Zheng L, YZ Wen, Fu GH*. Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma. Molecular Medicine Report. 2009;2:169-174（IF：0.22） |
| 20. |
Zou K, Yuan Z, Yang Z, Luo H, Sun K, Zhou L, Xiang J, Shi L, Yu Q, Zhang Y, Hou R, Wu J*.Production of offspring from a germline stem cell line derived from ovaries. Nature Cell Biology. 2009;11:631-636 (Table of Contents Cover Story)（IF：19.527） |
| 21. |
Yuan Z., Hou R., Wu J*.Generation of mice by transplantation of an adult spermatogonial cell line after cryopreservation. Cell proliferation.2009; 42:123- 131（IF：2.917） |
| 22. |
Zhang Y., Wu J*. Molecular cloning and characterization of a new gene, Oocyte- G1. J cell Physiol.2009; 218: 75-83 (Cover Story)（IF：4.586） |
| 23. |
Shi L, Wu J*. Epigenetic regulation in mammalian preimplantation embryo development. Reproductive Biology and Endocrinology.2009;7:59（IF：2.077） |
| 24. |
Zhang J, Song LP, Huang Y, Zhao Q, Zhao KW, Chen GQ*. Accumulation of hypoxia-inducible factor-1α protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid. haematologica.2008; 93(10).1480-1487（IF：6.416） |
| 25. |
Lu Y, Peng ZG, Yuan TT, Yin QQ, Xia L, Chen GQ*. Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity. Leukemia.2008; 22:378-386（IF：8.296） |
| 26. |
Peng ZG, Zhou MY, Huang Y, Qiu JH, Wang LS, Liao SH, Dong S, Chen GQ*. Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1α Oncogene.2008;27:839-847（IF：7.135） |
| 27. |
Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ*. Hypoxia-inducible factor-1α-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene.2008;27:519-527（IF：7.135） |
| 28. |
Yang L, Jiang Y, Wu SF, Zhou MY, Wu YL, Chen GQ*. CCAAT/enhancer-binding protein a antagonizes transcriptional activity of hypoxia-inducible factor 1 α with direct protein-protein interaction. Carcinogenesis.2008;29:291-298（IF：4.795） |
| 29. |
Huang Y, Qiu J, Chen GQ*, Dong S*. Coiled-coil domain of PML is essential for the aberrant dynamics of PML-RARa, resulting in sequestration and decreased mobility of SMRT. Biochemical and Biophysical Research Communications. 2008;365: 258-265（IF：2.548） |
| 30. |
Wang S, Zheng Y, Yu Y, Xia L, Chen GQ, Yang YZ, Wang LS. Phosphorylation of b-actin by protein kinase C-delta in camptothecin analog-induced leukemic cell apoptosis.Acta Pharmacol Sin.2008;29:135-142（IF：1.783） |
| 31. |
Liu J, Jackson CW, Gartner TK*.The Src requirement for washed platelet aggregation and dense granule secretion in response to stimulation by a low level gamma-thrombin. J Thromb Haemost. 2008;6:1035-7.（IF：6.069） |
| 32. |
Yang Y, Wu PP, Wu J, Shen WW, Wu YL, Fu AF, Zheng L, Jin XL, Fu GH*.Expression of anion exchanger 2 in human gastric cancer. Experimental Oncology. 2008;30:81-87.（IF：7.135） |
| 33. |
Li L, Wang J, Ye RD, Shi G, Jin H, Tang X, Yi J*.PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase. J Cell Physiol. 2008;217:486-493.（IF：4.586） |
| 34. |
Wang J, Yi J*.Cancer cell killing via ROS: to increase or decrease, that is the question.Cancer Biol Ther. 2008;7(12):1875-1884. （IF：2.711） |
| 35. |
Huang XZ, Wang J, Huang C, Chen YY, Shi GY, Hu QS, Yi J*.Emodin enhances cytotoxicity of chemotherapeutic drugs in prostate cancer cells: the mechanisms involve ROS-mediated suppression of multidrug resistance and hypoxia inducible factor-1.Cancer Biol Ther. 2008;7:468-475. （IF：2.711） |
| 36. |
Cai J, Niu X, Chen Y, Hu Q, Shi G, Wu H, Wang J, Yi J*.Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis. Neoplasia. 2008;10:41-51.（IF：5.025） |
| 37. |
Wang J, Li L, Cang H, Shi G, Yi J*.NADPH oxidase-derived reactive oxygen species are responsible for the high susceptibility to arsenic cytotoxicity in acute promyelocytic leukemia cells. Leukemia Res. 2008;32:429-436. （IF：2.358） |
| 38. |
Yu Q, Wu J*. Involvement of cyclins in mammalian spermatogenesis. Mol Cell Biochem. 2008;315:17-24.（IF：1.896） |
| 39. |
Yang Z, Wu J*.Mouse Dynein Axonemal Intermediate Chain 2: Cloning and Expression. DNA and Cell Biology.2008;27:479-488 (Cover Story)（IF：2.28） |
| 40. |
Wu J*, Zhang Y, Tian GG, Zou K, Lee CM, Yu Q, Yuan Z. Short-type PB-cadherin promotes self-renewal of spermatogonial stem cells via multiple signaling pathways. Cell Signal. 2008; 20:1052-1060（IF：4.094） |
| 41. |
Wang JH*, Lu Y, Wang JC, Koch AE, Zhang J, Taichman RS. CXCR6 induced prostate cancer progression by the AKT/mTOR signaling pathway. Cancer Research.2008,68(24):10367-10376.（IF：7.543） |
| 42. |
Yan H, Wang YC, Li D, Wang Y, Liu W, Wu YL, Chen GQ*. Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: the role of protein kinase Cd. Leukemia. 2007;21:1488-1495（IF：8.296） |
| 43. |
Yu Y, Wang LS, Shen SM, Xia L, Zhang L, Zhu YS, Chen GQ*. Subcellular proteome analysis of camptothecin analogue NSC606985-treated acute myeloid leukemic cells. Journal of Proteome Research.2007; 6:3808-3818（IF：5.132） |
| 44. |
Xu M, Li D, Lu Y, Chen GQ*. Leukemogenic AML1-ETO fusion protein increases carcinogen-DNA adduct formation with upregulated expression of cytochrome P450-1A1 gene. Experimental Hematology.2007;35:1249-1255（IF：3.106） |
| 45. |
Gao FH, Wang Q, Wu YL, Li X, Zhao KW, Chen GQ*. c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression. Biochemical and Biophysical Research Communications.2007;356:505-511（IF：2.548） |
| 46. |
Liu W, Zhu YS, Guo M, Yu Y, Chen GQ*.Therapeutic efficacy of NSC606985, a novel camptothecin analog, in a mouse model of acute promyelocytic leukemia. Leukemia Res. 2007;31:1565-1574（IF：2.358） |
| 47. |
Shen WW, Wu J, Cai L, Liu BY, Gao Y, Chen GQ, Fu GH*. Expression of anion exchanger 1 sequestrates p16 in the cytoplasm in gastric and colonic adenocarcinoma. Neoplasia.2007;9: 812-819（IF：5.025） |
| 48. |
Chen GQ*, Wang LS, Wu YL, Yu Y. Leukemia, an effective model for chemical biology and target therapy. Acta Pharmacol Sin.2007;28:1316-1324（IF：1.783） |
| 49. |
Cheng J, Kang X, Zhang S and Yeh ET*. SUMO-Specific protease 1 is essential for stabilization of HIF1α during hypoxia.Cell.2007;131:584-595.（IF：31.152） |
| 50. |
Wang Y, Wu SF, Chen GQ, Fu GH*.Effect of block deletions in the C-terminus on the functional expression of human anion exchanger 1 (AE1).Mol Membr Biol. 2007;24:65-73.（IF：2.777） |
| 51. |
Wang Y, Huang X, Cang H, Gao F, Yamamoto T, Osaki T, Yi J*.The endogenous reactive oxygen species promote NF-kappaB activation by targeting on activation of NF-kappaB-inducing kinase in oral squamous carcinoma cells. Free Radical Res. 2007;41:963-971.（IF：2.215） |
| 52. |
Zhang Y, Yang Z, Wu J*.Signaling pathways and preimplantation development of mammalian embryos. FEBS J.2007;274:4349-4359（IF：3.042） |
| 53. |
Yang Z, Wu J*. MicroRNAs and Regenerative Medicine. DNA and Cell Biology. 2007;26:257-246（IF：2.28） |
| 54. |
Wu J*, Tian Q. Role of follicle stimulating hormone and epidermal growth factor in the development of porcine preantral follicle in vitro. Zygote.2007;15:233-240（IF：1.262） |
| 55. |
Wu J*, Xu B, Wang W. Effects of luteinizing hormone and follicle stimulating hormone on the developmental competence of porcine preantral follicle oocytes grown in vitro. J Assist Reprod Genet.2007;24:419-424（IF：1.359） |
| 56. |
Zhang L, Wang LS, Xu Y, Xia L, Chen WL, Zheng Y, Chen GQ*. Comparative proteomic analysis of human leukemic cells with and without inducible expression of leukemogenic AML1-ETO protein.Chinese Journal of Physiology. 2006;49:182-191（IF：0.698） |
| 57. |
Pan XY, Chen GQ, Cai L, Buscemi S, Fu GH*.Anion exchanger 2 mediates the action of arsenic trioxide.British Journal of Haematology.2006;134:491-499（IF：4.597） |
| 58. |
Li X, Xu YB, Wang Q, Lu Y, Zheng Y, Wang YC, Lubbert M, Zhao KW, Chen GQ*. Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cells.J Cell Physiol. 2006;208:594-601.（IF：4.586） |
| 59. |
Huang Y, Zhao Q, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ*. Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells. Oncogene. 2006;25:6618-6627（IF：7.135） |
| 60. |
Han YH, Xia L, Song LP, Zheng Y, Chen WL, Zhang L, Huang Y, Chen GQ, Wang LS*.Comparative proteomic analysis of hypoxia-treated and untreated human leukemic U937 cells. Proteomics.2006;6:3262-3274（IF：4.426） |
| 61. |
Lu Y, Xu YB, Yuan TT, Song MG, Lubbert M, Fliegauf M, Chen GQ.Inducible expression of AML1-ETO fusion protein endows leukemic cells with susceptibility to extrinsic and intrinsic apoptosis.Leukemia.2006;20:1-7（IF：8.296） |
| 62. |
Wu YL, Dudognon C, Nguyen E, Hillion J, Pendino F, Tarkanyi I, Aradi J, Lanotte M, Tong JH, Chen GQ, Segal-Bendirdjian E*.Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. Journal of Cell Science.2006;119:2797-2806（IF：6.144） |
| 63. |
Guo M, Song LP, Jiang Y, Liu W, Yu Y, Chen GQ*.Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1α independent mechanisms.Apoptosis.2006; 11: 67-77（IF：4.066） |
| 64. |
Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ*. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia.BLOOD.2006. 107;2:698-707（IF：10.555） |
| 65. |
Jing Y, Yang J, Wang Y, Li H, Chen Y, Hu Q, Shi G, Tang X, Yi J*.Alteration of subcellular redox equilibrium and the consequent oxidative modification of nuclear factor kappaB are critical for anticancer cytotoxicity by emodin, a reactive oxygen species-producing agent.Free Radic Biol Med.2006;40:2183- 2197.（IF：6.081） |
| 66. |
Yang Z,Wu J*.Small RNAs and development. Med Sci Monit. 2006;12:RA125- 129.（IF：1.543） |
| 67. |
Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ*. Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. haematologica.2005; 90:1607-1616（IF：6.416） |
| 68. |
Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ, Chen GQ*. Interferon-a-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cd and JNK. J BIOL CHEM. 2005. 280;52:42707-42714（IF：5.328） |
| 69. |
Fu GH, Wang Y, Xi YH, Guo ZW, Liu XB, Bai SZ, Yang BF, Chen GQ*. As2O3 enhances the anion transport activity of band 3 and the action is related with the C-terminal 16 residues of the protein.Journal of Drug Targeting.2005;13:235-243（IF：2.885） |
| 70. |
Xue ZH, Jiang Y, Yu Y, Wang LS, Chen GQ, Zhao Q*. Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1α protein.Biochemical and Biophysical Research Communications.2005;332:1140-1145（IF：2.548） |
| 71. |
Jiang Y, Xue ZH, Shen WZ, Du KM, Yan H, Yu Y, Peng ZG, Song MG, Tong JH, Chen Z, Huang Y, Lubbert M, Chen GQ*.Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1α that augments transcriptional activity of CCAAT/enhancer-binding protein-a.Leukemia. 2005;19: 1239-1247（IF：8.296） |
| 72. |
Yu Y, Chen S, Wang LS, Chen WL, Guo WJ, Yan H, Zhang WH, Peng CH, Zhang SD, Li HW, Chen GQ*. Prediction of pancreatic cancer by serum biomarkers using surface-enhanced laser desorption/ionization-based decision tree classification.Oncology.2005;68:79-86（IF：7.135） |
| 73. |
Fu GH, Wang Y, Xi YH, Shen WW, Pan XY, Shen WZ, Jiang XS, Chen GQ*. Direct interaction and cooperative role of tumor suppressorp16 with band 3. FEBS Letters. 2005;579:2105-2110（IF：3.541） |
| 74. |
Song MG, Gao SM, Du KM, Xu M, Yu Y, Zhou YH, Wang Q, Chen Z, Zhu YS, Chen GQ*.Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cdelta-dependent mechanisms. BLOOD. 2005;105:3714-3721（IF：10.555） |
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